The International Symposium on Grids and Clouds (ISGC) 2016 will be held at Academia Sinica in Taipei, Taiwan from 13-18 March 2016, with co-located events and workshops. The conference is hosted by the Academia Sinica Grid Computing Centre (ASGC). The theme of ISGC 2016 focuses on“Ubiquitous e-infrastructures and Applications”. Contemporary research is impossible without a strong IT component – researchers rely on the existence of stable and widely available e-infrastructures and their higher level functions and properties. As a result of these expectations, e-Infrastructures are becoming ubiquitous, providing an environment that supports large scale collaborations that deal with global challenges as well as smaller and temporal research communities focusing on particular scientific problems. To support those diversified communities and their needs, the e-Infrastructures themselves are becoming more layered and multifaceted, supporting larger groups of applications. Following the call for the last year conference, ISGC 2016 continues its aim to bring together users and application developers with those responsible for the development and operation of multi-purpose ubiquitous e-Infrastructures. Topics of discussion include Physics (including HEP) and Engineering Applications, Biomedicine & Life Sciences Applications, Earth & Environmental Sciences & Biodiversity Applications, Humanities, Arts, and Social Sciences (HASS) Application, Virtual Research Environment (including Middleware, tools, services, workflow, etc.), Data Management, Big Data, Networking & Security, Infrastructure & Operations Management, Infrastructure Clouds and Virtualisation, Interoperability, Business Models & Sustainability, Highly Distributed Computing Systems, and High Performance & Technical Computing (HPTC), etc. The goal of ISGC 2016 is to create a face-to-face venue where individual communities and national representatives can present and share their contributions to the global puzzle and contribute thus to the solution of global challenges. We cordially invite and welcome your participation!